Pyrogen may refer to: Pyrogen (fever), a fever inducing substance. Pyrogen (pyrotechnics), a pyrotechnic composition producing flame when heated by e.g. a bridgewire

pyrogen Any substance that causes fever. Endogenous pyrogens are proteins, such as interleukin-1, released by white blood cells in response to bacterial or viral infections.

Pyrogens are fever-inducing substances, such as lipopolysaccharides (LPS) from Gram-negative bacteria (endotoxins), representing significant hazards as contaminants of health products (Montag-Lessing et al., 2010; Daneshian et al., 2008).

The USP now recognizes two tests - The Pyrogen Test conducted with rabbits and the Bacterial Endotoxins Test, also termed the Limulus Amebocyte Lysate (LAL) Test. Additionally, the agency has...

Today, bacterial pyrogens \b)\ are recognized as the causative agent responsible for many of those early fevers and for many of the other biological effects described incidental to parenteral...

…protein and polysaccharide substances called pyrogens, released either from bacteria or viruses or from destroyed cells of the body, are capable of raising the thermostat and causing a rise in body temperature. Fever is a highly significant indicator of disease. …system’s responses is to produce pyrogens.

A pyrogen is a substance causing induction of a febrile response (elevation of body temperature, fever) which can be fatal in humans and animals. The causal substance is usually a bacterial endotoxin, the lipopolysaccharide complex associated with the outer membrane of Gram-negative pathogens including, but not limited to, Escherichia coli ...

A pyrogen is a substance (infectious organisms or their product toxins or cytokines) that provokes fever. Exogenous pyrogens are substances, which originate outside the body and which are capable of inducing interleukins.

2021年7月23日 · Pyrogens are substances that induce fever. They act on the hypothalamic thermoregulatory center. They inhibit the heat-sensing neuron s while stimulating the cold-sensing neuron s, thus, resulting in the hypothalamus increasing body temperature above the normal range. The result is a condition called fever.

2022年10月16日 · Pyrogen or bacterial endotoxin testing are FDA-approved method of determining pyrogenic elements like endotoxin. These tests are essential for decreasing the risk of cross-infection in patients. Pyrogen testing differs from sterility testing, and both tests should be carried out simultaneously.