In biochemistry, a synthase is an enzyme that catalyses a synthesis process. Note that, originally, biochemical nomenclature distinguished synthetases and synthases. Under the original definition, synthases do not use energy from nucleoside triphosphates (such as ATP, GTP, CTP, TTP, and UTP), whereas synthetases do use nucleoside triphosphates.

Human mitochondrial (mt) ATP synthase, or complex V consists of two functional domains: F 1, situated in the mitochondrial matrix, and F o, located in the inner mitochondrial membrane. Complex V uses the energy created by the proton electrochemical gradient …

This review outlines a holistic framework for studying ATP synthase and emphasizes the importance of considering interactions with the lipid environment in shaping the function and evolutionary history of membrane proteins.

The mitochondrial ATP synthase (complex V) consists of two multisubunit components, F 0 and F 1, which are linked by a slender stalk. F 0 spans the lipid bilayer, forming a channel through which protons can cross the membrane.

2023年9月13日 · ATP synthase, also known as F 1 F 0 ATPase or complex V, is the 5th subunit of the oxidative phosphorylation complex. It uses the energy from the electrochemical gradient of protons created by the electron transport chain to produce ATP from ADP.

2020年1月28日 · ATP synthase is an enzyme that directly generates adenosine triphosphate (ATP) during the process of cellular respiration. ATP is the main energy molecule used in cells.

2001年9月1日 · ATP synthase is a ubiquitous, highly conserved enzyme that catalyses the formation of ATP from ADP and P i using a unique rotary motor mechanism. The enzyme is located in the inner membrane of...

2019年3月7日 · Since ATP is the major energy currency in all living cells, its synthesis and function have widely been studied over the last few decades uncovering several aspects of ATP synthase. This review intends to summarize the structure, function and inhibition of …

ATP synthase has two distinct components: the peripheral membrane protein F 1 and the integral membrane protein F o (the letter o, not the number 0; from the fact that it is the site at which the inhibitor oligomycin binds) (Figure 25.1).

2020年12月31日 · ATP synthase is a huge molecular complex (>500,000 daltons) embedded in the inner membrane of mitochondria. Its function is to convert the energy of protons (H+) moving down their concentration …