Best practices for single-cell analysis across modalities | Nature ...
2023年3月31日 · Recent advances in single-cell technologies have enabled high-throughput molecular profiling of cells across modalities and locations. Single-cell transcriptomics data can now be...
Construction of a human cell landscape at single-cell level | Nature
2020年3月25日 · Here we use single-cell mRNA sequencing to determine the cell-type composition of all major human organs and construct a scheme for the human cell landscape (HCL). We have uncovered a...
The technological landscape and applications of single-cell ... - Nature
2023年6月6日 · We highlight the impact that single-cell multi-omics technologies have had in cell lineage tracing, tissue-specific and cell-specific atlas production, tumour immunology and cancer...
Single-cell analysis reveals T cell infiltration in old neurogenic ...
The analysis of 14,685 single-cell transcriptomes reveals a decrease in activated neural stem cells, changes in endothelial cells and microglia, and an infiltration of T cells in old neurogenic niches.
Comprehensive single-cell transcriptional profiling of a ... - AAAS
2017年8月18日 · To resolve cellular heterogeneity, we developed a combinatorial indexing strategy to profile the transcriptomes of single cells or nuclei, termed sci-RNA-seq (single-cell combinatorial indexing RNA sequencing).
Almost all single-cell studies contain visu-alizations — sometimes called t-SNE or UMAP plots — which represent single cells as points on a 2D plane. Studying how those points aggregate, or...
Construction of a human cell landscape at single-cell level
Here we use single-cell mRNA sequencing to determine the cell-type composition of all major human organs and construct a scheme for the human cell landscape (HCL). We have uncovered a single-cell hierarchy for many tissues that have not been well characterized.
The technological landscape and applications of single-cell
We highlight the impact that single-cell multi-omics technologies have had in cell lineage tracing, tissue-specific and cell-specific atlas production, tumour immunology and cancer genetics, and in mapping of cellular spatial information in fundamental and translational research.
Single-cell sequencing techniques from individual to ... - Nature
2020年9月15日 · Here, we review single-cell sequencing techniques for individual and multiomics profiling in single cells. We mainly describe single-cell genomic, epigenomic, and transcriptomic methods,...
New technology tracks millions of cells simultaneously during …
1 天前 · Thanks to a new technology called Moscot ("Multi-Omics Single-Cell Optimal Transport"), researchers can now observe millions of cells simultaneously as they develop into a new organ-for example, a ...
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