Lineal (poloxamers or Pluronic ®) or X-shaped (poloxamines or Tetronic ®) amphiphilic tri-block copolymers of poly (ethylene oxide) and poly (propylene oxide) (PEO-PPO-PEO) have been broadly explored for controlled drug delivery in different regenerative medicine approaches.

1997年10月1日 · Applications of amphiphilic block copolymers, and in particular PEO/PPO copolymers, are reviewed in [15-,29,30-,31,32,33-]. We start this review with the topic of PEO-PPO-PEO block copolymers in dilute aqueous solutions (micelles), where new information on micelle formation and structure in water and in the presence of cosolutes is examined.

Pluronic P123 is a symmetric triblock copolymer comprising poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) in an alternating linear fashion, PEO-PPO-PEO.

Poloxamer 188, a triblock copolymer of poly (ethylene oxide) (PEO) and poly (propylene oxide) (PPO), protects cellular membranes from various stresses. Though numerous block copolymer variants exist, evaluation of alternative architecture, composition, and size has been minimal.

2015年11月5日 · Poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide) triblock copolymers, Pluronic (PEO–PPO–PEO), are water-soluble nonionic polymer surfactants and can self-assemble into micelles above the critical micelle temperature (CMT) or the critical micelle concentration (CMC) in aqueous solutions [1], [2], [3], [4].

The triblock poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) based systems, PEO-PPO-PEO, show thermoreversible gelation around body temperature and, therefore, are particularly suitable for biomedical applications such as …

2003年12月5日 · Properties of nonionic triblock copolymers of poly (ethylene oxide) (PEO) and poly (propylene oxide) (PPO) (EO n PO m EO n) in aqueous solution and their interaction with the ionic surfactants sodium dodecyl sulfate and hexadecyltrimethylammonium chloride have been investigated by static and dynamic light scattering, high sensitivity differentia...

2006年3月1日 · Aiming at developing biodegradable thermo-responsive polymers that display enhanced rheological properties, a family of PEO–PPO–PEO based poly (ether ester urethane)s, was developed. The materials were produced following a two-step synthetic pathway.