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• A 85 yo Female with a hx of HTN, CHF and OA is taking the following meds: – Tylenol 500-1000mg BID prn – Meloxicam 7.5mg qday prn – Lisinopril 20 mg qday – Dyazide (HCTZ/Triamterene) 25/37.5mg 1 qday – Spironolactone 25mg 1 qday • Her BPs appear to fluctuate from 120- 130/70-80 to 150-160/90s. • Her recent labs show a Cr of 1.3 and a K of 5.2 • Could there be DDI at play here? . . . • NSAIDS and Antihypertensive Med • NSAIDs inhibit prostaglandin synthesis which results in inhibition of renal

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