Electrophilic Substitution Reaction - Mechanism, Types, Examples

7.12: The SN1 Mechanism

SOLVED: Why do carboxylic acids not undergo nucleophilic acyl substitution reactions with amines?Amines are bases and will deprotonate the carboxylic acid. Amines will undergo an addition reaction and just add onto the carbon since they are poor leaving groups. Amines will cause it to undergo an elimination reaction.

Is nucleophilic acyl substitution SN2? - TimesMojo

Nucleophilic Acyl Substitution (With Negatively Charged Nucleophiles)

Lecture 8 , nucleophilic substitution